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Associate Principal Scientist, Neurogenetics


West Point, PA
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Job Details

Job Title: Associate Principal Scientist, Neurogenetics  - RES001882

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its 125-year legacy. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

The candidate will leverage human genetics to identify and functionally validate novel targets and pathways for therapeutic intervention in diseases such as ALS and Parkinson disease. The successful candidate will serve as a hands-on experimentalist that applies functional genomic tools, cellular and molecular biology and animal models to validate human genetic targets identified through genome-wide association studies (GWAS) and Mendelian disease genomics. The position requires an individual with a keen attention to detail and the innate sense of urgency necessary for rapid experimental iteration. Given the team-based responsibilities of the position, strong collaboration and communication skills are required.


  • PhD or equivalent

  • An understanding of human genetics and the tools used to identify disease-associated genetic variation
  • Strong in vitro and cell biology techniques including primary and recombinant cell culture, molecular cloning and gene expression in human cellular systems, Western blotting, immunocytochemistry, etc. 
  • Strong communication, collaboration, including an ability to communicate experiment design, results and conclusions in a clear and concise manner. 
  • Experience in characterizing cellular pathology, protein aggregation, organelle function 
  • Disease area knowledge in neurodegeneration 
  • Experience with genetic manipulation and cell-based assays using primary and iPSC-derived cell types
  • Experience with in vivo disease models (rodent)

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. If you need an accommodation for the application process please email us at
Search Firm Representatives Please Read Carefully: 
Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.
For more information about personal rights under Equal Employment Opportunity, visit:

Job Research Science Generic

Primary Location NA-US-PA-West Point

Other Locations NA-US-MA-Boston

Employee Status Regular

Number Of Openings 1

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