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Associate Principal Scientist, PPDM - Bioanalytics


South San Francisco, CA
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Job Details

Job Title: Associate Principal Scientist, PPDM - Bioanalytics  - RES001817

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research.  Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery.
At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.
As an Associate Principal Scientist, you will work with a collaborative and cross-functional team of scientists from both PPDM and Discovery Research.  
  • The successful candidate may serve as supervisor on projects, and will be required to provide training and coaching to professional staff.
  • Responsible for overseeing adherence to appropriate protocols and other guidelines as they pertain to LC-MS/MS method validation, sample analysis and data analysis for new chemical entities, metabolites and biomarkers in biological fluids and tissues.
  • Other responsibilities will involve overseeing the designing and execution of new LC-MS/MS quantitative analysis methods for small and large molecules in preclinical studies.
  • Will have a unique opportunity to develop innovative bioanalytical approaches in support of Merck's pipeline dedicated to developing novel therapeutic agents.
Additional responsibilities include and are not limited to the following:
  • Supervision in developing novel sample preparation approaches and LC-MS/MS quantitative methods for new xenobiotics.
  • Collaboration with PPDM and discovery team members to interrogate pharmacokinetic and metabolism related questions to advance programs.
  • Designing new experimental approaches ultimately with technology transfer to Merck scientists
To accomplish the above, the successful candidate must have a unique combination of strong scientific background and experimental skills, able to combine theoretical and experimental knowledge in chemistry and analytical technologies to solve the most challenging bioanalytical problem. 

Required Education / Work Experience:
  • BS in Chemistry, Biochemistry, Pharmaceutical Sciences or related field with (12) years experience in Bioanalysis
  • MS in Chemistry, Biochemistry, Pharmaceutical Sciences or related field with (8) years experience in Bioanalysis
  • Ph.D. degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with (4) years experience in Bioanalysis
Required Experience:
  • Broad understanding of the drug discovery and/or development process and PPDM science (e.g. PK calculations, data interpretation and how data is used)
  • Advanced experience in quantitation of multiple analytes (i.e. xenobiotics, biomarkers) in samples from ADME, MOA, PK/PD, and pre-clinical studies via LC-MS/MS. Proved hands-on processing of pre-clinical and ADME samples (e.g. blood, urine, CSF, etc.) using purification techniques
  • Significant experience in MS data analysis and operation of mass spectrometers and associated LC and software systems
  • Advanced in upkeep, maintenance and trouble shooting of LC-MS/MS systems, and skills in the training of others
  • Capable of independent interactions with vendors and external scientists for establishment of new technologies or integration of new workflows
Preferred Experience:
  • Outstanding interpersonal, collaboration and verbal/written communications skills and ability to excel in a team-based environment
  • Ability to multi-task in a highly dynamic environment and flexibility to work in a fast-paced team in a professional and pleasant manner is a necessity
  • Ability to design experiments, interpret and track results, and utilize this information to enable assay development
  • History of publication in peer-reviewed journals


The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at 
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.  Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for us all.

Job Research Science

Primary Location NA-US-CA-South San Francisco

Other Locations 

Employee Status Regular

Number Of Openings 1

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