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Postdoctoral Research Fellow – Biologics Process Development

Merck


Location:
NJ-Kenilworth, NJ
Date:
08/17/2017
2017-08-172017-09-16
Job Code:
POS000222
Merck
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Job Details

Job Title: Postdoctoral Research Fellow – Biologics Process Development  - POS000222

Description

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.


Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 


Be a part of the legacy: Merck Postdoctoral Research Fellow Program

The Merck Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution
committed to breakthrough innovation in research and discovery.

Position overview:

As a postdoctoral fellow in Biologics Process Development & Clinical Manufacturing department you will work with a highly collaborative team of Merck scientists, Postdoctoral researchers and external collaborators to utilize a combination of fundamental science (Systems Biology) and engineering/advanced mathematical modeling via multivariate Data Analysis (MVDA) to increase productivity, improve process robustness and product quality and reduce production costs of therapeutic proteins derived from mammalian cell culture processes.  Development, execution and analysis of hypothesis driven cell culture experiments will be a key component of the research position.

Responsibilities include but are not limited to:
  • Design, test and implement transcriptomics, proteomics, metabolomics, and other ‘omics approaches in cell culture process development
  • Collaborate internally and externally to develop and implement new approaches to monitor identified potential key biomarkers at real-time to support on-line process control, medium and process optimization
  • Assess and monitor activity of cellular secretory pathway via intracellular trafficking and extracellular protein analyses
  • Publications on ‘omics analyses and models based on MVDA approaches


Qualifications
Education Minimum Requirement: 
  • PhD in the field of Systems Biology or related discipline with 3 years or less of postdoctoral experience.
Required Experience and Skills: 
  • Hands-on experience in sample preparation and data analysis for one or more areas of Systems Biology, including transcriptomics, proteomics, metabolomics, and other ‘omics workflow.
  • Ability to apply statistical designs and analyses to understand and improve mammalian cell culture processes
  • Excellent scientific understanding of biology and engineering principles for mammalian cell culture, including cell biology and metabolism, medium optimization, process development
  • Strong skills in critical thinking, laboratory experimentation and data analysis.
  • Track record of scientific contributions (including peer-reviewed manuscripts), and strong verbal and written communication and interpersonal skills
Preferred Experience and Skills:
  • Hands-on experience with applying and integrating Systems Biology tools and computational analyses to understand cell biology and metabolism.
  • Experience with interpreting data generated from HPLC, NMR, mass spectroscopy, genomics, transcriptomics, metabolomics, lipidomics, peptidomics or proteomics analyses
  • Knowledge of metabolic pathways, intracellular trafficking and secretory pathways for eukaryotic and prokaryotic systems

Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.
 
Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service. 
mrlpostdoc


Job Post-Doctoral Fellow

Primary Location NA-US-NJ-Kenilworth

Other Locations 

Employee Status Regular

Number Of Openings 1

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