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Postdoctoral Research Fellow - Metabolism

Emulate, Inc.


Location:
Boston, Massachusetts 02210
Date:
04/10/2017
Job Type:
Employee
Job Status:
Full Time
Emulate, Inc.
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Job Details

Role Description:

An exciting postdoctoral opportunity, working with an innovative Organ-on-Chip technology, is available for a highly-motivated individual.  The Organ-on-Chip platform combines design, engineering, and biology to create a human microengineered system that recreates human biology and disease in vitro.  This position will focus on the Kidney-Chip to characterize biochemical, genetic, epigenetic, and pharmacological determinants for the uptake and transport of monoclonal antibody drugs across various cell types and human tissues. Individuals with demonstrated experience in cellular, molecular, and biochemical techniques such as gene cloning, gene expression assays, epigenetic analysis, protein expression and quantification, advanced cell culture approaches (e.g. live cell imaging, transcytosis assays, induced pluripotent stem cell models, co-cultures), microscopy, immunohistochemistry, and bioinformatics, are strongly encouraged to apply. 

 

 

Key Responsibilities:

  •  Act independently to design, lead, and conduct experiments to characterize and evaluate an emerging Organ-on-Chip technology platform centered on assessing drug-transporter interactions
  • Establish collaborations with experts in adjacent scientific fields as needed for successful interpretation of all data
  • Evaluate and translate a complex set of data
  • Publish as primary author in peer-reviewed journal articles, abstracts, and/or patents
  • Communicate problems, ideas and suggestions
  • Lead preparation and communication of presentations
  • Understand and comply with ethical, legal and regulatory requirements applicable to our business
  • Transfer knowledge to technical staff by providing training and appropriate oversight to ensure competency 

Requirements

Desired Skills & Experience:

  •  Ph.D. in Biochemistry, Microbiology, Biology, Cell Biology, Physiology, Molecular Medicine, Pharmaceutical Sciences or other related area with a focus on in vitro cellular systems, primary cell systems or related discipline required
  • 0-3 years’ post-graduate experience
  • Drug transporter and pharmacology expertise and practical in vitro experience with a background in pharmacokinetics/pharmacodynamics highly desired
  • Demonstrated expertise in area of research
  • Knowledge base on kidney in vitro models and applications to ADMETox field a plus
  • Working knowledge of human tissue samples highly desired
  • Experience in independent design of research experiments a plus
  • Strong verbal and written communication skills with demonstrated ability for novelty and consistency in experimental studies
  • Publications in peer reviewed journal are prerequisite
  • Must have excellent lab, communication, and presentation skills with ability to work closely within multidisciplinary team
Equal Opportunities:

 

This is an Equal Employment Opportunity Employer that is committed to inclusion and diversity. We take unbiased action to offer employment and advancement opportunities to all applicants, including minorities, women, protected veterans, and individuals with disabilities. Our methods for hiring include ensuring that all available opportunities are fairly promoted - via online globally available channels - in a manner accessible to all potential applicants.

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