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Scientist, ADME (Absorption Distribution Metabolism Excretion)


South San Francisco, CA
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Job Details

Job Title: Scientist, ADME (Absorption Distribution Metabolism Excretion)  - RES001883

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research.  Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery.
At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.
This position will support Merck's drug discovery and development efforts in the Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) at the multi-disciplinary South San Francisco site.
  • The primary role will be to generate and interpret high quality in vitro PPDM data, partnering with drug discovery teams to enable the invention of novel therapeutics.
  • Performing assays according to standard protocols
  • Opportunities to develop novel approaches to address PPDM-related issues.  

Education /Work Experience Requirement:
  • Bachelor’s degree in Biochemistry, Chemistry, Pharmacology, Chemical Engineering or related filed with a minimum of (3) years’ experience in Drug Metabolism & Pharmacokinetics
  • Master’s degree in Biochemistry, Chemistry, Pharmacology, Chemical Engineering or related filed with a minimum of (1) year experience in Drug Metabolism & Pharmacokinetics


Required Experience:
  • Experience in performing in vitro drug metabolism studies (e.g. metabolic stability, plasma protein binding, blood to plasma ratios and/or reaction phenotyping) according to given protocols
  • Experience in bioanalysis using LC-MS/MS
  • Strong communication and collaboration skills
Preferred Experience:
  • Experience using Electronic Laboratory Notebooks, Analyst and Microsoft Office
  • LC-MS/MS trouble-shooting ability
  • Assay method development
The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at 
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.  Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for us all.

Job Research Science

Primary Location NA-US-CA-South San Francisco

Other Locations 

Employee Status Regular

Number Of Openings 1

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