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Scientist, Formulation Sciences

Blueprint Medicines

Cambridge, Massachusetts 02139
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Full Time
Blueprint Medicines
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Job Details

Blueprint Medicines is seeking an exceptional candidate for a Scientist of Formulation Sciences.  The candidate will contribute to the planning and execution of all activities related to the development and manufacturing of small molecule oral drug formulations, in support of Blueprint Medicines’ pre-clinical and clinical programs.


  • Design, oversee and interpret characterization experiments for potential drug development candidates in collaboration with Discovery chemists.
  • Support phase-appropriate formulation development to enable non-GLP and GLP pre-clinical studies, as well as clinical development.
  • Manage multiple CROs and CMOs during various phases of pharmaceutical development, including drug substance characterization and drug product manufacturing, GLP and GMP, for small molecules.
  • Contribute to the design and oversight of drug product manufacturing and process characterization activities.
  • Monitor drug product characterization and stability studies to ensure optimal formulation development and selection.
  • Support technical drug product manufacturing and process transfer activities.
  • Represent formulation sciences on internal, CRO and CMO project teams.
  • Collaborate with Quality operations to review and approve master and executed batch records, manage variances and oversee investigations.
  • Coordinate and collaborate with Process Chemistry and Supply Operations to monitor and plan appropriately to support drug product clinical needs.
  • Establish and maintain effective working relationships with key internal and external stakeholders.

Qualifications and Capabilities:

  • B.S degree in pharmaceutics, chemical engineering or material sciences with 5-8 years or PhD with 1-2 years as a team member of various drug development programs.
  • Experience with small molecule oral drug formulations is required.
  • Experience managing relationships with CROs, CMOs and testing labs.
  • Knowledge of small molecule and solid oral dosage forms.
  • Understanding of the drug product formulation process, quality and regulatory development
  • Understanding of the physical and chemical characterization of molecules, including solid state and solution properties.
  • Experience with technologies to enhance poorly soluble and/or bioavailable candidates and the physical and chemical characterization of molecules
  • Ability to effectively prioritize and manage multiple projects and tasks
  • At home in a results-driven, highly accountable environment where you can make a clear impact
  • A team player, who listens effectively and invites response and discussion
  • A collaborator who communicates in an open, clear, complete, timely and consistent manner

All applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.


Blueprint Medicines’ mission is to dramatically improve the lives of patients with genomically defined diseases. Our singular focus is to use our deep understanding of the genetic blueprint of cancer and other diseases driven by the abnormal activation of kinases to craft highly selective medicines aimed at eradicating these diseases.

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.

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