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Scientist - Immunology


Boston, MA
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Job Title: Scientist - Immunology  - BIO004864


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

The Discovery organization seeks an outstanding candidate to join the Therapeutic Area – Autoimmune and Inflammation Group. This Scientist role will focus on designing and performing experiments using functional in vitro and ex vivo cell-based immunoassays to advance drug discovery research programs from target validation through to lead identification. Broad expertise in cell biology is required for this role, with preference given to candidates with demonstrated experience in immunology drug discovery and development. The successful candidate will have deep scientific curiosity, excellent oral and written communication skills, the ability to function independently and as part of a team, and be able to work on multiple projects simultaneously. With limited supervision, the role includes developing and optimizing methodologies and assays as well as planning, designing, and executing experiments using good scientific judgment. The position is a hands-on, laboratory based role with no direct reports (individual contributor).



  • Degree in immunology, cell biology, pharmacology, biochemistry or related field with 3 years’ experience (Masters) or 5 years’ experience (Bachelor's) in the pharmaceutical/biotech industry or in an academic setting. 

  • Rodent and human cell line and primary immune cell tissue culture skills.
  • Ability to independently design, perform and interpret data derived from cellular immune function assays (e.g., immunocyte differentiation, proliferation, cytotoxicity, cytokine production). 
  • Broad expertise and familiarity with assays and technologies commonly used to assess immune endpoints (e.g., MLR, antigen-specific T-cell/APC cultures, ELISA, Mesoscale). 
  • Experience with tissue processing and cell isolation technologies (e.g., Ficoll separation, Miltenyi AutoMACS, FACS sorting). 
  • Experience in multi-parameter flow (FACS) and/or mass (CyTOF) cytometry and proficiency in subsequent downstream data analysis using programs such as FlowJo, FACSDiva, Cytobank, etc. 
  • Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds. 
  • Candidate should be a strong team player with a demonstrated ability to work independently to design and execute experiments, organized and interpret data, troubleshoot, and suggest next steps. 

  • Cell manipulation and engineering towards assay development and target validation (e.g., plasmid/RNAi delivery, CRISPR/Cas9 genomic editing, clonal selection and optimization). 
  • In vivo experience: ability to perform (or willingness to learn) basic mouse handling and manipulation techniques (injections, post-mortem tissue collection). 
  • Molecular biology: PCR/NanoString technologies, Western Blot. 
  • Ability to mentor and guide other scientists in the group as needed. 
  • Ability to intellectually contribute to immunology drug discovery research programs, including identification and validation of novel targets.
  • Ability to work with external academic, biotechnology, and contract research organizations.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. If you need an accommodation for the application process please email us at


Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.


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Job Biology-Discovery

Primary Location NA-US-MA-Boston

Other Locations 

Employee Status Regular

Number Of Openings 1

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