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Merck Sharpe & Dohme Corp

West Point, Pennsylvania 19486
Job Type:
Job Status:
Full Time
Merck Sharpe & Dohme Corp
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Job Details

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.


West Point, PA
Job # PHA001427

This position will support Merck's drug discovery and early clinical development efforts within the ADME group of the Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM). The primary role of the successful candidate will be to develop, execute and foster translational Pharmacokinetic Pharmacodynamic (TPKPD) and other useful quantitative pharmacology applications on program teams in a discovery setting. The candidate will be expected to serve as a representative in multi-disciplinary teams providing expertise, guidance and hands-on support for the application of quantitative pharmacology sciences to address key questions and issues. The candidate will also be expected to support various internal and/or external scientific initiatives, such as the development and application of novel physiologically-based pharmacokinetic (PBPK) approaches.

Knowledge of drug metabolism sciences (ADME - Absorption-Distribution-Metabolism-Excretion) and pharmacodynamics are required. Responsibilities will also include presenting analyses to governance committees as well as preparing documentation for regulatory submissions.


* MS in biopharmaceutics, pharmaceutical sciences, pharmacometrics, computational biology/chemistry, or a related field with an additional 4+ years of relevant pharmaceutical industry experience
* Ph.D. in biopharmaceutics, pharmaceutical sciences, pharmacometrics, computational biology/chemistry, or a related field Obtained on or before June 2018 with relevant pharmaceutical industry experience

* Strong scientific background in pharmacokinetics, pharmacodynamics and drug metabolism (ADME) sciences
* Excellent communication, problem solving and leadership skills
* Experience and proficiency using modeling software such as Phoenix, simCYP, Matlab, NONMEM, etc.

* Experience in serving on multidisciplinary project teams

Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at

To be considered for this position, please visit our career site at, search jobs, create a profile and submit your resume for requisition #PHA001427 to:

Merck is an equal opportunity employer, Minority/Female/Disability/Veteran - proudly embracing diversity in all of its manifestations.

For more information about personal rights under Equal Employment Opportunity, visit:
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