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Senior Scientist, Cellular Pharmacology

Merck


Location:
Boston, MA
Date:
07/19/2017
2017-07-192017-08-18
Job Code:
PHA001383
Merck
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Job Details

Job Title: Senior Scientist, Cellular Pharmacology  - PHA001383

Description
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its 125-year legacy. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
 
The In Vitro Pharmacology department is seeking a highly motivated and creative scientist to join the Cellular Pharmacology group in Boston to focus on early drug discovery projects in support of target and pathway validation for several therapeutic areas for genetically validated targets. The successful applicant will independently design and implement In Vitro/ Ex Vivo cell-based assays, using genetic and pharmacological manipulations in relevant cellular systems. Main responsibilities will include cell-based assay development, high-content imaging and flow cytometry analyses. Solid experience in cell culture, cell line generation and biosample processing is a must with preference given to candidates with direct experience in primary or 3-D cell culture approaches. Hands-on contributions are essential. The candidate is expected to work both independently and collaboratively with colleagues in Pharmacology, the Genetics and Pharmacogenomics group, and across other departments, and demonstrate excellent organizational, communication and presentation skills. A successful candidate will have a track record of achievements and publications in academic or industrial settings.


The specific responsibilities of the candidate include but are not limited to: 
  • Design and execution of experimental strategies for target and pathway validation
  • Implementation and validation of various cellular in vitro and ex vivo assays using a wide range of methodologies
  • Cell line generation utilizing state-of-the art genetic manipulations and gene knock-down techniques
  • Establishment of primary cell cultures, including 3D and co-cultures from different organs
  • Proper documentation and reporting of the experimental findings and scientific contributions to research projects/programs in multiple disease areas
  • Effective collaboration with members within department and across functional teams in support of research projects/programs at different stages. 



Qualifications
Education:  
  • A Master’s degree in Biology or related disciple with a minimum of 5 years relevant industry experience or PhD (preferred) in Biological Science or related discipline with a minimum of 3 years post-doctoral experience. 

Required: 
  • Extensive job related laboratory research experience with tissue culture, cell line generation and cellular assay execution in academic or industrial setting. 
  • Hands-on cellular assay development and troubleshooting skills, and proficiency with different cellular screening formats 
  • Solid data analytical and problem solving skills and proficiency in standard scientific software used for data analysis 
  • Excellent oral and written communication skills, including preparation of study reports, presentations and manuscripts for publication in peer-reviewed scientific journals.
  • Proven ability to function and communicate effectively in a multi-disciplinary environment and thrive in a team environment.

Preferred: 
  • Research and drug discovery experience with target and pathway validation
  • Experience with primary cell and 3D cell cultures
  • A broad set of assay skills in molecular biology, DNA, RNA and protein techniques is strongly preferred
  • Knowledge of state-of-the-art screening approaches, and familiarity with lab automation
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.  If you need an accommodation for the application process please email us at staffingaadar@merck.com.
  
Search Firm Representatives Please Read Carefully: 
Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.
 
For more information about personal rights under Equal Employment Opportunity, visit:
 
           
           


Job Pharmacology - DPS

Primary Location NA-US-MA-Boston

Other Locations 

Employee Status Regular

Number Of Openings 1

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