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Senior Scientist, PPDM - Bioanalytics


South San Francisco, CA
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Job Title: Senior Scientist, PPDM - Bioanalytics  - RES001854

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research.  Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery.
At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Merck is currently seeking exceptional LC-MS/MS Bioanalystis for positions within the Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) Department located at our South San Francisco site.

As a Senior Scientist, you will work with a collaborative and cross-functional team of scientists from both PPDM and Discovery Research. The responsibilities will involve designing, planning and executing new approaches for the quantitative analysis of exogenous and endogenous compounds in preclinical studies using advanced analytical technologies. The candidate will have a unique opportunity to develop innovative bioanalytical approaches in support of Merck's pipeline dedicated to developing novel therapeutic agents.

Responsibilities include but are not limited to the following:

  • Developing robust sample preparation approaches and LC-MS/MS methods for quantitative analysis
  • Analysis and interpretation of LC-MS /MS data
  • To accomplish the above, the successful candidate must have excellent interpersonal, collaboration and communication skills in a team environment

Required Education / Work Experience:
  • BS in Chemistry, Biochemistry, Pharmaceutical Sciences or related field with (7) years experience in Bioanalysis
  • MS in Chemistry, Biochemistry, Pharmaceutical Sciences or related field with (4) years experience in Bioanalysis
  • Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, or met all requirements of a Ph.D. by June 2017

Required Experience:

  • Understanding of the drug discovery and/or development process and PPDM science (e.g. PK calculations, data interpretation and how data is used).
  • Established experience in quantitation of multiple analytes (i.e. xenobiotics, biomarkers) in samples from ADME, MOA, PK/PD, and pre-clinical studies via LC-MS/MS. Proved hands-on processing of pre-clinical and ADME samples (e.g. blood, urine, CSF, etc.) using purification techniques.
  • Proficient in upkeep, maintenance and trouble shooting of instruments and developing technical expertise.
  • Proficient in software tools, informatics, and data management related to specialized area of work.
  • Demonstrated ability to analyze MS data and basic understanding of pharmacokinetics parameters.

Preferred Experience:

  • Excellent verbal and written communications skills and ability to work in a team based environment
  • Ability to multi-task in a highly dynamic environment and flexibility to work in a fast-paced team in a professional and pleasant manner is a necessity
  • Ability to design experiments, interpret and track results, and utilize this information to enable assay development
  • History of publication in peer-reviewed journals
The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at 
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.  Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for us all.

Job Research Science

Primary Location NA-US-CA-South San Francisco

Other Locations 

Employee Status Regular

Number Of Openings 2

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