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Senior Scientist, Vaccine Drug Product Development

Merck


Location:
West Point, PA
Date:
08/30/2017
2017-08-302017-09-29
Job Code:
BIO004912
Merck
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Job Details

Job Title: Senior Scientist, Vaccine Drug Product Development  - BIO004912

Description

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.


Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 


The Vaccine Drug Product Development in Merck Research Laboratories, West Point, PA is seeking a Senior Scientist or Engineer to join our department.  The successful candidate will be expected to work as part of a team that is focused on the development of mRNA lipid nanoparticle (LNP) based vaccines.  The main responsibilities include the design, execution, and documentation of experiments to evaluate the impact of formulation composition and the drug product manufacturing process on yield and stability of liquid and lyophilized products.  


The successful candidate will be able to work in a fast-paced team environment, able to contribute to multiple programs, and be able to learn new skills quickly.  The candidate should possess technical knowledge and experience related to development and characterization of lipid nanoparticle or mRNA-based drug product formulations.  Additionally, candidate should have knowledge and / or experience related to parenteral formulation development, biochemical and biophysical characterization methodologies, particle size analysis, and lyophilization or other drying technologies.  Good documentation practices, strong communication and collaborations skills are essential.




Qualifications

Education:  

  • A Master's Degree in Chemical/Biochemical Engineering, Chemistry, Biochemistry, Virology, or related discipline, with a minimum of four (4) years of process development experience, OR a Ph.D. in Chemical/Biochemical Engineering, Chemistry, Biochemistry, Virology, or related discipline.

Required: 

  • Experience in development and characterization of lipid and/or polymeric nanoparticle based formulations
  • Strong understanding, knowledge and experience with drug product development and characterization of nucleic acid or lipid nanoparticle based products
  • Understanding of liquid and lyophilized formulation development and the drug product manufacturing process.
  • Experience in development/characterization of drug product manufacturing unit operations (freeze/thaw, mixing, sterile filtration, filling, stoppering, visual inspection, etc.).
  • Proven written and verbal communication skills 
  • Strong organizational and technical problem solving abilities
  • Ability to work in a fast-paced team environment

Preferred:

  • Experience with preparation and manufacturing of safety assessment and clinical supplies.
  • Experience with analytical characterization of mRNA or LNP-based products including particle size analysis, capillary electrophoresis, and other biochemical and biophysical methodologies.
  • General knowledge and/or experience with synthesis of lipid nanoparticles
  • Drug product process development experience with a variety of large biological molecules and/or live virus vaccines for parenteral administration
  • General knowledge and/or experience with lyophilization, including techniques to examine residual moisture, the physical properties of lyophilized formulations, scale up and technical transfer considerations.
  • Experience in development/characterization of drug product manufacturing unit operations (freeze/thaw, mixing, sterile filtration, filling, stoppering, visual inspection, etc.).
  • Understanding of process related stresses that impact the quality and stability of vaccines
  • Experience with manufacturing of clinical supplies

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 

 

If you need an accommodation for the application process please email us at staffingaadar@merck.com.

  

Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

 

For more information about personal rights under Equal Employment Opportunity, visit:

 

            

            



Job Biologics, Vaccines, Analytical Formulat

Primary Location NA-US-PA-West Point

Other Locations 

Employee Status Regular

Number Of Openings 1

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