REGENXBIO is searching for a research scientist to support discovery research and conduct early proof of concept studies in the field of gene therapy. The role requires practical knowledge of AAV vectors and their use in animal models. Extensive and current hands-on experience in tissue processing, RT-PCR/quantitative PCR, Immunohistochemistry and ELISA is required. Work experience using viral vectors such as AAV, Adenovirus or Lenti virus in in vivo/ in vitro models is desired. Good communication and documentation skills are essential.
Collaborate with the Research and Development team to conduct proof of concept studies
Develop methods to assess in vivo distribution of AAV vectors
Develop methods to process tissues from animal models to do immunohistochemistry and Realtime PCR analysis
Assist in lab management tasks, such as material inventory, ordering and equipment maintenance.
Maintain impeccable records from raw data including data books and computer-generated data files, quantitative analysis of data, laboratory protocols, and summary reports.
Presents data at internal meetings, scientific conferences and to external collaborators.
SKILLS, KNOWLEDGE AND ABILITIES REQUIRED
BS with 8-10+, Master with 6-8+ or Ph.D. with 0-3 years of post-PhD experience in research and development of gene therapy products
Experience with animal models and cell culture is required
Specific hands on skills and familiarity with tissue processing, immunohistochemistry analysis, qPCR analysis, ELISA, etc.
Knowledge of Flow cytometry and Microscopy is desirable.
Excellent team player with good interpersonal skills.
Excellent oral and written communication skills for effectively interfacing with internal and external organizations
Detail oriented, organized, technically competent and be able to perform hands on work in the laboratory.
WORKING CONDITIONS AND/OR PHYSICAL REQUIREMENTS
This position may require the following conditions:
Sitting or standing for extended periods
Lifting to 30 lbs
Travel up to 20%
Individuals will be required to work in a biosafety level 2 lab
Need to be able to focus on executing tasks under verbal and written instructions, as well as distinguish colors, sensory touch, able to hear and read procedures while working.
The working condition will be in climate-controlled room temperature between 15-30 C
There will be some exposures to chemicals and biologics but under proper protection and ventilations
Internal Number: RE-19-00007
REGENXBIO is a leading clinical-stage biotechnology company seeking to improve lives through the curative potential of gene therapy. REGENXBIO's NAV® Technology Platform, a proprietary adeno-associated virus (AAV) gene delivery platform, consists of exclusive rights to more than 100 novel AAV vectors, including AAV7, AAV8, AAV9 and AAVrh10. REGENXBIO and its third-party NAV Technology Platform Licensees are applying the NAV Technology Platform in the development of a broad pipeline of candidates in multiple therapeutic areas.
Our gene therapy product candidates are designed to deliver genes to cells to address genetic defects or to enable cells in the body to produce therapeutic proteins that are intended to impact disease. Through a single administration, our gene therapy product candidates are designed to provide long-lasting effects, potentially significantly altering the course of disease and delivering improved patient outcomes. We are currently developing gene therapy product candidates for the treatment of retinal, metabolic, and neurodegenerative diseases. Our product candidates all utilize AAV viral vectors from our proprietary gene delivery platform, which we call our ...NAV Technology Platform. In addition to our internal product candidate programs, we also selectively license our NAV Vectors to other leading biotechnology companies.