The SeniorScientist, Analytical Development will be responsible for designing and executing analytical development laboratory projects to support Astex CMC projects. He/she will be a leader in the development of scientifically sound analytical methods, method troubleshooting, and detection/identification/quantitation of impurities. The incumbent may play a role in method transfers to CMO’s. He/she will contribute in a CMC team environment to solve API and drug product technical problems and meet project timelines.
Develop analytical methods for drug substance, intermediates, and drug products in an in-house laboratory according to agreed objectives and timelines
Independently perform hands on bench work and apply expertise to a range of assignments, such as improving drug product sample preparation procedures, performing complex UHPLC method development, identifying impurities and tracking them using mass spectrometry, and conducting method robustness studies
Perform characterization and interpretation of the LC-MS profiles to determine the impurities present in a sample
Perform in-house lab work to provide technical input for investigations and in troubleshooting of OOT/OOS results from batch testing and stability studies
Maintain current knowledge of relevant pharmaceutical analytical techniques.
Lead the acquisition, training and maintenance of analytical instrumentation
Ph.D. in analytical chemistry preferred, with at least 3 years relevant experience in a pharmaceutical analytical R&D environment. Strong candidates with other combinations of education and experience will be considered.
Knowledge of organic chemistry to support chemical process development and understanding of impurities and degradation products
Hands-on experience with the primary analytical methods for the testing of small molecules
HPLC/UHPLC method development experience
Mass spectrometry expertise
Effective communication skills for interfacing with Astex personnel and domestic/international contract laboratories
Problem-solving focus, with demonstrated initiative and results
Highly motivated, with a bias for action
Employer will assist with relocation costs.
Internal Number: 19-35R
About Astex Pharmaceuticals
Our corporate mission is to discover and develop novel therapeutics with a primary focus in cancer and a developing focus in CNS disorders.