Pfizer is seeking a dynamic and collaborative experimental scientist for a Principal Scientist position contributing to ADME (absorption, disposition, metabolism and excretion) sciences in the in vitro enzymology and preclinical pharmacokinetics (PK) group.
The individual will be joining a dynamic group in ADME Sciences Enzymology, Department of Medicine Design, in support of the global Pfizer small molecule discovery research and development portfolio. The qualified candidate will be responsible for design, conduct and advancing in vitro enzymology, oversight of nonclinical pharmacokinetic studies, and/or modeling and simulation studies in support of ADME principles for programs. The individual will be a member of matrix teams comprised of other ADME discipline scientists and led by a project representative, with expectations that integrated information resolves ADME issues and advances programs. The role includes supervision and mentorship of laboratory staff, responsibility for experimental conduct or oversight, and resource management relevant to our therapeutic areas. The individual will also be expected to advance scientific understanding, grow effective partnerships externally as well as internally to incorporate growing technological advances, and incorporate novel experimental approaches to address challenging dispositional issues.
Provide scientific leadership and enzymology knowledge or expertise for lab-based portfolio support and scientific innovation relevant to ADME sciences.Relevant areas include understanding of drug clearance, tissue binding and disposition, reaction phenotyping, enzyme kinetics, enzyme inhibition/induction or relevant DDI data generation, and delivery or conduct of quality preliminary or definitive ADME studies in support of regulatory filings.
Working with modeling and simulation scientists, take scientific leadership for the predictions of clearance (IVIVE) and drug-drug interactions.This includes directing or undertaking physiologically based PK (PBPK) modeling strategies, which support and achieve project goals or address regulatory interactions.
Advise discovery and development project teams regarding approaches to understand and optimize dispositional attributes and to address any regulatory filings for clinical candidates.
Continue to build Pfizer’s strong external network in PK and enzymology sciences to integrate advances at academic centers (eg tissue co-culture, MPS, tissue impairment) with our internal strategy and capabilities, and where appropriate, to progress precompetitive topics via collaborations and consortia.
Guide and develop laboratory-based scientists focused on the design and conduct of novel low- and medium-throughput in vitro assays to support discovery and definitive development assays for regulatory filings.
Review and approve DMPK study protocols, research reports, nonclinical ADME summaries, and abstracts/manuscripts for publication.
Direct original research aligned with the research priorities established by the Medicine Design Strategic Imperatives and Business Plan, as well as ongoing assay conduct to support the Pfizer discovery and development portfolio.
Proactively establish and grow effective partnerships externally as well as internally across multiple disciplines (e.g. Clinical Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Computational Sciences, High Throughput Screening) to advance scientific innovation in the realm of ADME and to develop synergistic packages of scientific capabilities to support the portfolio.
PhD or equivalent with 2+ years of relevant postdoctoral academic or industry experience in the scientific field.Candidates with a diverse scientific background (eg pharmaceutical sciences, drug metabolism, pharmacokinetics, biochemistry, chemistry, biology, biomedical sciences, or engineering) are encouraged to apply.
A keen interest in growing knowledge and optimizing dispositional attributes of small molecules through ADME enzymology science and technology is required.
Experience working in matrix teams within and across technical/research line organizations, a collaborative problem solver.
Training in people and organizational leadership skills and supervisory skills.
Strong leadership and interpersonal skills as well as a track record of enthusiasm to deliver results in a fast-paced environment.
Highly effective written, presentation and verbal communication skills are essential.
In-depth knowledge and experience in relevant areas of small molecule enzymology science and technology (eg phenotyping, competitive and/or time-dependent enzyme inhibition, induction, protein binding, tissue distribution, microsomal, hepatocyte and tissue fraction studies, or tissue culture).
ADME project representation or small molecule discovery and development experience.
Experience in pharmacokinetic data analysis (e.g. noncompartmental analysis), understanding of therapeutic exposure-effect relationships, and hands-on experience with physiologically-based (PBPK) modeling using tools such as Watson, Phoenix WinNonlin, Berkeley Madonna, MATLAB, and/or Simcyp is desirable.
Recognition for creativity and innovation through strong publication/presentation record.
Experience in advanced cell culture techniques such as co-culture or tissue engineering (eg MPS) experience is highly desirable.
Proficiency in the use of Microsoft Office Suite of tools (Outlook, Word, Excel, etc.) and hands-on experience establishing IVIVE, computational ADME predictions, and data visualization tools.
Conduct of experiments will require the scientist to work in the laboratory, including standing, walking, sitting, and lifting solvents.
Non-Standard Work Schedule, Travel or Environment Requirements
Periodic travel will be required to other Pfizer sites (eg Cambridge, MA; La Jolla, CA) or to attend and present at scientific conferences.
Other Job Details:
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Employer will assist with relocation costs.
Internal Number: 4769898
About Pfizer Inc.
At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products. Our global portfolio includes medicines and vaccines as well as many of the world's best-known consumer health care products. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time.
At Pfizer, we’re driven to discover the cure—driven to significantly improve the lives of everyone...everywhere. If you’re similarly driven, you’ll find there’s no better place to begin—and continue—your career than at Pfizer.