People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.
The following opportunity exists in our South San Francisco, CA headquarters:
Senior Scientific Researcher - Cytometry Biomarker Development
We are seeking a highly motivated Scientific Researcher/Senior Scientific Researcher to join the Cytometry Biomarker group within Development Sciences. Our group is responsible for designing and implementing biomarker assays for programs in clinical development at Genentech in immunology, immuno-oncology, hematological oncology, and other new therapeutic areas.
Who You Are
The successful candidate will join our dynamic team and work to design and implement flow cytometry biomarkers in early and late stage clinical trials of novel therapeutics in our growing pipeline. The desired candidate will have a solid understanding of immunology and cancer biology; demonstrate strong expertise in immunological cell subsets such as effector and regulatory T, B, and/or monocyte subsets; and understand the biomarkers used in flow cytometry to identify these populations in vivo.
Attention to detail, good communication, and collaboration skills will be essential to excel in this position
Proven cell biology expertise working with a variety of sample types including whole blood, bone marrow, cell lines and single-cell suspension from tissue samples is expected
Ability to design and execute the development and validation of 8+ color cytometry assays is essential
Experience with and enthusiasm for higher complexity (+18 color) cytometry platforms is preferred
Experience with advanced bioinformatics tools (e.g. ‘R’ scripts, spotfire) for analyzing and visualizing biomarker data is highly valued
Strong analytical skills and judgment in assessing the quality of assay data and assay performance will be needed to be successful in this role
Must be self-motivated, able to multi-task, and meet timelines efficiently and productively
Scope of position:
This position will report to the Senior Scientific Manager of the Cytometry Biomarker group within the Development Sciences Division of Genentech Research and Early Development. The individual will lead development and execution of cytometry biomarker activities supporting one or more molecules and indications in the non-oncology and oncology disease areas to better understand mechanisms of drug action, response and resistance. Scope of biomarker activities will span predictive, pharmacodynamic, and prognostic biomarkers as well as response markers such as MRD (minimal residual disease).
B.A./B.S. or M.S degree in life sciences, with at least 3 years of relevant experience, preferably in the industry setting, is required. A strong knowledge of flow cytometry is essential, with proficiency in traditional manual gating approaches such as FCS Express or FloJo®. Candidates with enthusiasm and experience to adopt advanced analytical tools such as unsupervised and supervised automated analysis (e.g. tSNE, FLOWDensity, FLOWSom) will be given preference. Hands-on lab experience with human cell based assays is preferred. The candidate must demonstrate a high level of independence and be able to develop hypotheses and analysis plans for immunology and oncology associated cytometry biomarker data. The candidate will have a demonstrated ability to function as part of a cross-functional team. Strong writing and communication skills are required, as evidenced by publications and/or drug development reports. Experience with outsourcing flow cytometry assays to contract research organizations (CRO) is highly desirable.
Who We Are
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and
life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
The next step is yours. To apply today, click on the "Apply online" button.
Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.
At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.