Job Seekers, Welcome to AAPS Career Development Center
Search Filters
Use this area to filter your search results. Each filter option allows for multiple selections.
Search Results: 14 Jobs
Save Agent
Loading... Please wait.
Circle Pharma

South San francisco, California

Moderna

Cambridge, Massachusetts

Moderna

Cambridge, Massachusetts

Moderna

Cambridge, Massachusetts

Moderna

01239, Massachusetts

D. E. Shaw Research Logo
D. E. Shaw Research

New York, New York

Pfizer, Inc. Logo
Pfizer, Inc.

Lake Forest, Illinois

Pfizer Inc. Logo
Pfizer Inc.

Andover, Massachusetts

Selecta Biosciences, Inc.

Watertown, Massachusetts

Loading... Please wait.
Expand Show Other Jobs
Job Saved Save Job
Sr. Scientist, DMPK
Circle Pharma
Email Print
About Circle Pharma
Circle has developed a new paradigm for macrocycle drug discovery, combining structure-based rational design and advanced synthetic chemistry. Our platform facilitates the design and synthesis of intrinsically cell-permeable macrocycles that can address both intra- and extra-cellular therapeutic targets, and can be delivered by multiple routes, including oral administration. While the platform can be applied to challenging targets across a wide range of serious diseases, our pipeline is focused on developing macrocycles against intracellular protein-protein interactions that are key drivers in cancer. Our lead programs target cyclin proteins, including cyclins A and E, which are part of the regulatory machinery that controls progression of cells through the cell cycle. Inhibition of cyclin A has been reported to be synthetic lethal to cancer cells that carry mutations causing dysregulation of the Retinoblastoma (Rb) pathway; we are researching the potential of macrocycles that inhibit cyclin A in a broad range of cancer types including small cell lung cancer (SCLC) where mutations in the Rb gene occur at a high frequency. Cyclin E is upregulated in many tumor types including ute...rine and ovarian cancer and is often associated with resistance to widely used cancer therapies, including trastuzumab and cdk4/6 inhibitors. Cyclin E is also implicated in diseases beyond cancer.
Connections working at Circle Pharma
https://careers.aaps.org/jobs/17157370/sr-scientist-dmpk
Loading. Please wait.