1+ months

Scientist II - Reagent Development

Roche
Pleasanton, CA

POSITION SUMMARY:

The NGS workflow controls and references team (NGSWaR) develops orthogonal control and reference methods for the RSS assay development team.  NGSWaR also identifies and tests cutting edge reagents, technologies or protocols that are supporting the development of products in Oncology, Genetics, Infectious Disease and Automation/Sample Preparation. Areas of interest include short and long read sequencing technologies, low input and difficult sample preparation methods and creating integrated workflows. Candidates must be able to work in a collaborative, exciting, and fast-paced team environment. Also responsible for operating and maintaining equipment, interacting with LIMS databases, completing projects in a timely fashion, research and development,  and giving presentations at weekly meetings.

ESSENTIAL FUNCTIONS:

  • Experience with short and/or long read sequencing technology
  • Operation of different genomics analysis technologies such as microarrays, real time PCR and ancillary equipment for quality control and validation.
  • Develops, validates, and applies methods for various genomics methods mainly focused on sequencing.
  • Processes include nucleic acid isolation and quantification, PCR amplification, library preparation, plate normalizations and.
  • Working with senior personnel, performs early development activity to create new workflows that are robust, cost-effective and time efficient.
  • Collaborates with R&D to transfer new assays and methods to automation platforms.
  • Develops project timelines and utilizes time management practices and tools to manage demands and deadlines and to deliver on key project milestones.
  • Accurately and consistently records experimental methods, materials and results in electronic laboratory notebooks.  Analyzes data, evaluates results, forms conclusions, and determines future experiments.
  • Uses broad knowledge of molecular biology technique to proactively troubleshoot assays, to resolve technical issues and challenges, and to perform data interpretation.
  • Implements standard operation procedures SOPs.
  • Presents work including scientific background information and project updates at internal staff meetings and at cross-functional team meetings.
  • Determines all chemicals, reagents and supplies needed for a project; develops a strong knowledge of all related third-party vendors and their technologies and products.
  • Establishes and maintains productive relationship with personnel in development; orients and trains new R&D personnel as needed.

MINIMUM REQUIREMENTS;

  • Bachelorâs degree in Biological/Life Sciences, Chemistry, Biochemistry or related field with a minimum of 3 years of lab experience
  • Strong molecular biology background
  • Experience in assay design, optimization, validation, experimental design, data analysis, and presentation.
  • Experience performing  next-generation sequencing methods (Exome, whole genome, RNA sequencing)
  • Excellent communication skills

Preferred

  • Experience in: Laboratory automation/liquid handling; Microarrays (Affymetrix and Illumina; Real-time PCR; Advanced molecular biology techniques used in Genomics
  • Ability to write SOP
  • Next-generation sequencing using Illumina instruments such as HiSeq, Nextseq, MiSeq
Posted: 2018-12-20 Expires: 2019-03-21

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Scientist II - Reagent Development

Roche
Pleasanton, CA

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