D. E. Shaw Research is seeking pre-clinical translational scientists with experience in drug discovery to join our New York–based team. This is a high-visibility, high-impact role that affords the opportunity to help shape our drug discovery programs. Responsibilities include working collaboratively with our team of computational scientists and consultants on target evaluation, selection, and translational strategy; overseeing experimental work at our CRO partners from the design and implementation of functional cell assays to in vivo testing; and providing strategic advice regarding new drug discovery opportunities across therapeutic areas.

Relevant areas of experience include leadership of pre-clinical drug discovery programs, design of in vitro assays as well as in vivo disease models, and formulation of translational plans.  Specific knowledge of any of these areas is less critical, however, than strong research and communication skills, and a record of impact in drug discovery.

A successful hire will directly contribute to projects within our expanding portfolio of drug discovery programs, which we pursue both independently and in collaboration with leaders in academia and industry.

We are committed to fostering a stimulating, rewarding, and flexible work environment, and we offer above-market compensation.  In addition, we strive to support the personal and professional needs of our team members by offering generous benefits, opportunities for community engagement, and a variety of learning and development programs.

To submit an application, please use the link provided below:

https://apply.deshawresearch.com/careers/Register?pipelineId=865&source=American+Associate+of+Pharmaceutical+Scientists

D. E. Shaw Research (DESRES) is a New York-based drug discovery and computational biochemistry research company developing and using advanced computational technologies to understand the behavior of biologically and pharmaceutically significant molecules at an atomic level of detail, and to design precisely targeted, highly selective drugs for the treatment of various diseases.  Among our core technologies is a proprietary special-purpose supercomputer called ANTON® which we designed and constructed to perform molecular dynamics simulations more than 100 times faster than the world's fastest general-purpose supercomputers.  DESRES develops and refines advanced biomolecular modeling methods, software, and machine learning techniques on ANTON®, as well as on general-purpose supercomputers, in order to pursue both internal and collaborative drug discovery programs.

D. E. Shaw Research is an equal opportunity employer, dedicated to the goal of building a diverse workforce. We embrace diversity along all dimensions, and respect and value the unique qualities, perspectives, and identities of every person in our group. We welcome inquiries from all exceptionally well-qualified applicants, regardless of race, color, nationality, national or ethnic origin, religion or religious belief, caste, gender identity, pregnancy, caregiver status, age, military service eligibility, veteran status, sexual orientation, marital or civil partner status, disability, or status in any other category protected in this regard by law in any jurisdiction in which we operate.

About D. E. Shaw Research

D. E. Shaw Research is an independent research laboratory that conducts scientific research and technological development in the field of computational biochemistry. Our group focuses on the design of novel algorithms and machine architectures for high-speed MD simulations of proteins and other biological macromolecules, with the aim of significantly advancing the process of drug discovery. We have designed and developed multiple generations of ANTON®, a massively parallel supercomputer that executes MD simulations orders of magnitude faster than was previously possible. Anton has now simulated the behavior of a number of proteins for several milliseconds, revealing biologically and pharmaceutically relevant aspects of protein dynamics.

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